The original anime Zombieland Saga aired on 4 October 2018 and was broadcasted on AT-X, Tokyo MX, Sun TV, BS11, Saga TV, TVQ, along with Crunchyroll.

The anime was animated by Studio MAPPA and produced by Cygames in collaboration with Avex Pictures. The series' music will be produced by Avex Pictures, while dugout is producing the sound.

Both the opening theme song "Adabana Necromancy" (徒花ネクロマンシー, lit. "Fruitless Necromancy") and the ending theme song "Hikari e" (光へ, lit. "To the Light") are image songs performed in character by the voice actresses Hondo, Tano, Taneda, Kawase, Kinugawa, and Tanaka.